This report analyzes the relative availability, concentration, and wages of STEM (science, technology, engineering, and math) talent across twenty of the largest regional labor markets in the United States. The pace of technological change continues to accelerate. Employers require sophisticated skill sets rooted in STEM. The future economic development of cities and regions also depends on their ability to attract and retain that talent. The purpose of this report is to therefore give investors, enterprises, and local government a top-level comparison of regional labor dynamics and distribution of STEM talent.